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- Ea (Mesopotamian god)
- Eadbald (king of Kent)
- Eanatum (king of Lagash)
- Earnshaw, Thomas (clockmaker)
- Edgar (king of Wessex)
- Edward (Prince of Wales, 'the Black Prince')
- Edward II (king of England)
- Edward III (king of England)
- Edward 'the Confessor' (king of England)
- Edward 'the Elder' (king of Wessex)
- Edward VII (king of the United Kingdom of Great Britain and Ireland)
- Egerton, Thomas (keeper of the Great Seal)
- Elijah (Old Testament prophet)
- Elizabeth I (queen of England)
- Elizabeth II (queen of the United Kingdom of Great Britain and Northern Ireland)
- Enlil (Mesopotamian god)
- Entemena (king of Lagash)
- Epiktetos (Greek vase painter)
- Epstein, Jacob (artist)
- Erasmus, Desiderius (humanist scholar)
- Erechtheus (legendary king of Greece)
- Eric Bloodaxe (Viking king of York)
- Eros (Greek god)
- Esarhaddon (king of Assyria)
- Esigie (oba of Benin)
- Este, Isabella d' (Marchioness of Ferrara)
- Este, Leonello d' (Marquis of Ferrara)
- Estes, Richard (artist)
- Etana (legendary king of Kish)
- Ethelflaed ('Lady of the Mercians')
- Ethelred I (king of Wessex)
- Ethelred II (king of England)
- Eustace (Christian saint)
- Evagoras (king of Salamis)
- Evans, Merlyn (artist)
- Evans, Sir Arthur John (archaeologist)
- Exekias (Greek vase painter)